Development of Catalytic Reactions for Precise Control of Chemoselectivity
نویسندگان
چکیده
Catalytic chemoselective reactions of innately less reactive functionalities over more are described. A cooperative catalyst comprising a soft Lewis acid/hard Brønsted base enabled activation hydroxyl group an amino group, allowing for nucleophilic addition to electron-deficient olefins. The reaction could be applicable variety alcohols, including pharmaceuticals, without requiring tedious protection–deprotection process. Chemoselective enolization and subsequent α-functionalization carboxylic acid derivatives were also achieved by redox active through the radical process, providing unnatural α-amino/hydroxy bearing complex carbon framework diverse set functionalities. present catalysis described herein offers new opportunities expand chemical space innovative drug discovery research.
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ژورنال
عنوان ژورنال: Chemical & Pharmaceutical Bulletin
سال: 2021
ISSN: ['0009-2363', '1347-5223']
DOI: https://doi.org/10.1248/cpb.c21-00092